Light in womb 'gives healthy eyes' - in mice

Light passing through the body and into the womb has an important role in the developing eye, US researchers have discovered.

A study, published in the journal Nature, showed that mice spending pregnancy in complete darkness had babies with altered eye development.

It indicated tiny quantities of light were needed to control blood vessel growth in the eye.

The researchers hope the findings will aid understanding of eye disorders.

Now scientists - at the University of California, San Francisco, and Cincinnati Children's Hospital Medical Center - believe that body-penetrating light can alter the development of the eye, at least in mice.

Normally, a network of blood vessels known as the hyaloid vasculature is formed to help nourish the retina as it is constructed.

However, the blood vessels would disrupt sight if they remained, so they are later removed - like scaffolding from a finished building.

The researchers said this did not happen when the pregnancy was spent in total darkness.

The critical period was around 16 days - which is very late in mouse gestation, but corresponds to the first trimester in people.

The researchers hope their findings may aid understanding of human diseases of the eye, as many are down to blood vessels.

Some babies born prematurely develop "retinopathy of prematurity", when the blood vessels in the eye grow abnormally resulting in damage to the retina and a loss of vision.

Prof Lang said: "In retinopathy of prematurity there is overgrowth of blood vessels and that's what you see in these mice."

The researchers showed that light was activating in the mice a protein, melanopsin, which also has a role in regulating the body clock, and is present in people. However, whether the same processes take place in people or other animals is unknown.